Fatih Kurtuldu
<fatih.kurtuldu@tnuni.sk>

Fatih Kurtuldu completed his undergraduate education in Metallurgical and Material Engineering at Kocaeli University and he received his M.Sc. degree in Material Science and Engineering from Gebze Technical University, Turkey in 2015. His master thesis consist of investigate the possibility of using as a biomaterial of a glass-ceramic which can be obtained with an heat treatment from natural bone ash containing glasses. From 2015 to 2017 he was a research assistant at the Sakarya University in Turkey. During that period he worked on Atmospheric pressure plasma system for surface activation and Aluminum Nitride nanowire production.

As of November 2017, he has joined FunGlass as a PhD Student. His dissertation topic is “Mesoporous and hollow glass microspheres for selective targeting of cancer cells”.


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Mesoporous Glass Microspheres for Selective Targeting of Cancer Cells
1*Fatih Kurtuld, 1Dušan Galusek and 2Aldo R. Boccaccini
1Centre for Functional and Surface Functionalized Glass, Alexander Dubcek University in Trencin
2Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, Germany

MCM-41 ordered mesoporous silica was first developed in 1992 by Mobile Research and Development Corporation [1], and proposed as a drug delivery system in 2001 by Vallet-Regi et al. [2]. Since then, silica based ordered glass microspheres, such as MCM-41, SBA-15 or MCM-48 type ordered mesoporous glass materials have been consider as an ideal material for incorporation of drugs, genes and other therapeutic agent carriers and control release systems, since it decreases the systemic dose delivered to the patient and simultaneously conveys a very high and controllable localized drug dose at the diseased site. Research in this area is focused mainly at functionalization of the surface of mesoporous materials with tunable pore diameter, narrow pore size distribution, and high surface area.

Such drug delivery system is also a promising candidate for localized cancer treatment. It can control the rate and period of the drug delivery at targeted, diseased site of the body. Commonly used drug delivery systems based on organic materials are very successful and used in a broad area of medical and pharmaceutical applications. However, the organic systems tend to release drugs already before getting to targeted area. Successful incorporation of drugs, and zero-release before getting into targeted area can be achieved by surface modification of bioactive glass particles. The modification would include functional groups that allow the anchorage of certain therapeutic molecules, in processes that may be governed by external stimuli such as temperature, electric field, magnetic field, and light, or by internal stimuli such as, pH, redox potential, or the use of enzymes.

References:

[1]  C. T. Kresge, M. E. Leonowicz, W. J. Roth, J. C. Vartuli, and J. S. Beck, “Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism,” Nature, vol. 359, no. 6397, pp. 710–712, 1992.

[2]  M. Vallet-Regi, A. Rámila, R. P. Del Real, and J. Pérez-Pariente, “A new property of MCM-41: Drug delivery system,” Chem. Mater., vol. 13, no. 2, pp. 308–311, 2001.

Acknowledgement:

This abstract is a part of dissemination activities of project FunGlass.
This project has received funding from the European Union´s Horizon 2020
research and innovation programme under grant agreement No 739566.