Nusrat Sharmin <Nusrat.Sharmin@nottingham.edu.cn>
Dr Sharmin is currently employed as an assistant professor in the University of Nottingham Ningbo China in the department of Chemical and environmental engineering. Her field of expertise is fibre reinforced composites for biomedical, marine and aerospace applications. Her current research is focused on the use of phosphate glass fibres to reinforce bioresorbable polymers for bone fracture fixation applications. Dr. Sharmin completed her PhD in Materials Engineering and Materials Design from The University of Nottingham UK. Dr Sharmin has published more than 15 papers on biomaterials.
Durability of Phosphate Based Glasses: Effect of Composition
Nusrat Sharmin*1, Andrew J. Parsons2 and Ifty Ahmed3
1 Department of Chemical and Environmental Engineering, University of Nottingham, Ningbo, China
2Composites Research Group, University of Nottingham, UK
3Advanced Materials Research Group, University of Nottingham, UK
Phosphate glasses are unique group of materials that offer great potential for hard and soft tissue engineering over other types of bioactive glasses due to their fully resorbable characteristics, with some formulations possessing chemical composition similar to the mineral phase of natural bone. Therefore, for the last few decades, there has been a growing interest in using phosphate-based glasses for biomedical applications. Phosphate based glasses (PBGs) are known to show good bioactive characteristics and could be potentially used as favourable templates for bone-tissue formation. The biocompatibility of these glasses is hugely affected by the glass composition which could be easily altered via the addition of different modifying oxide. Moreover, the release of different ions from the glasses during degradation can also influence the bioactivity of the glasses. Therefore, it is very important to engineer the glass compositions wisely to achieve a suitable degradation and ion release rate. The main aim of this current work was to establish a relationship between the ion release, degradation rate and cytocompatibility of PBGs. Different modified oxides (Fe2O3, B2O3, SrO, Al2O3) were added to the glasses and the effect of composition on the durability of the glasses were studied. Ion release studies were conducted using Inductively Coupled Plasma Spectroscopic method. In order to observe the relationship between the ion release, degradation rate and cytocompatibility of the glasses cell culture studies were conducted using human osteoblast like (MG63) cell lines. It was revealed that the glasses containing both B2O3 and Fe2O3 maintained and showed higher cell viability as compared to the only Fe2O3 or B2O3 or SrO or Al2O3 containing glasses. This positive effect of glass composition on the cytocomapatibility properties of PBGs was mainly associated with the degradation and corresponding ion release rate. 31P NMR study was also conducted on the glasses to reveal the effect of composition on the structure of the glasses. The NMR result showed that the addition different modifier oxide largely affect he chain the structure of the glassed which eventually affected the degradation rate.